Powell, who is one of only seven players retained from their opening defeat to Brive in the Amlin Challenge Cup, packs down at No 8 alongside flankers Richie Vernon and Kearnan Myall.
Second-row Fraser McKenzie and prop Tony Buckley are the only other players retained up front while Rob Miller, Johnny Leota, Tom Brady and Will Addison keep their starting places in the backs. Though, Miller starts at fly-half and Addison at full-back.
James Gaskell, Sam Tuitupou and David Seymour are among those who drop to the bench.
Spanish champions Rugby Club La Vila travel to Sale following a 50-10 defeat to Agen in their opening match of the competition.
Sale Sharks: Addison, Brady, Leota, Davies, Higgins, Miller, Willis, Cobilas, Jones, Buckley, McKenzie, Lewaravu, Myall, Vernon, Powell (capt). Replacements: Taylor, Imiolek, Thomas, Gaskell, Seymour, Cliff, Burrell, Tuitupou.
CR La Vila: Ramirez, Llorens, Knight, Reid, Poggi, McCashin, Quirelli; Orrego, Phipps, Hutchinson, Cleary, Walker, Davies, Els, Cook. Replacements: Previtera, Fuster, Samper, Ruiz, Gonzales, Hebrard, Carmona, Evans.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.