De Luca replaces Rory Lamont, who suffered a broken leg during the defeat by France.
Sean Lamont will move outside to replace his brother on the wing with De Luca starting at centre in Dublin.
Max Evans, who was cleared of an assault charge on Monday at Edinburgh Sheriff Court, is on the bench after recovering from an ankle injury.
Euan Murray, who missed the Sunday defeat by France for religious reasons, is also on the bench along with Ruaridh Jackson, who has recently overcome a hamstring injury.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.