The South Sea Islanders will be looking to build on their 42-12 win over Canada in Colwyn Bay last Friday, and gain revenge for their World Cup defeat at the hands of Wales in New Zealand last year.
Kahn Fotuali'i, in superb form for the Ospreys this season, comes in for Jeremy Su'a, while Harlequins flanker Maurie Fa'asavalu replaces Tivani Foma'i.
Former Sale back Paul Williams returns from injury to start in the centre, while there is no place in the starting line-up for Robert Lilomaiava, the four-try hero of the win over Canada, as Worcester's Lemi takes the left-wing slot.
Faatoina Autagavaia is selected at full-back with James So'oialo suspended after being found guilty of a shoulder charge against Canada, although he could yet feature as the Samoa management plan to appeal the International Rugby Board ruling.
Daniel Leo also joins Teofilo Paulo in the second row as the tourists eye another Cardiff upset to go with their 1991 and 1999 triumphs, with Wales hurting after defeat to Argentina.
Only seven substitutes have been named on the bench, with the final player to be added in due course.
Former Leicester wing Alesana Tuilagi and ex-London Irish centre Seilala Mapusua were unavailable for the tour due to injury.
Samoa team to face Wales at the Millennium Stadium on Friday: F Autagavaia (Northland), P Perez (Eastern Province), G Pisi (Northampton), P Williams (Stade Francais), D Lemi (Worcester, captain), T Pisi (Suntory), K Fotuali'i (Ospreys); S Taulafo (Wasps), O Avei (Bordeaux-Begles), C Johnston (Toulouse); D Leo (Perpignan), T Paulo (North Harbour); O Treviranus (London Irish), M Fa'asavalu (Harlequins), T Tuifua (Newcastle).
Replacements: T Paulo (Clermont Auvergne), V Afatia (Agen), J Johnston (Harlequins), TBA, T Fomai (Hawke's Bay), J Su'a (Tasman), J Leota (Sale), R Lilomaiava (Laulii).
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