Ben Morgan showed England what they were missing with a hat-trick of tries in Gloucester's triumph.
A crowd of almost 10,000 saw Gloucester have the game won by the interval before sloppy play allowed the Welsh to compete more favourably in the second half.
Morgan and Freddie Burns, who were both released from the England squad for the game, were at the heart of the action.
Number eight Morgan claimed his try haul and also impressed with driving runs, while Burns was creative and collected 14 points with the boot.
Shane Monahan, Akapusi Qera and Koree Britton also claimed tries for the hosts, while Nick Scott and James Tideswell responded for a well-beaten Exiles side.
Exeter secured their second victory in this season's competition with a 23-13 win over the Ospreys which keeps them in contention to finish top of Pool One.
a 22-metre penalty, but an error from Exeter captain Junior Poluleuligaga led to Ospreys scoring the opening try through number eight Morgan Allen.
Slade missed a penalty before the Chiefs scored their first try with 12 minutes of the first half remaining.
The home side were initially stopped short of the line, but when the ball was recycled lock Will Carrick-Smith found his way over.
Slade added the simple conversion but Ospreys were quickly back on level terms with a long range penalty from fly-half Davies.
Slade missed another penalty just before the break, but the Chiefs kept pressing for the second try and Myles Dorrian picked up from the ruck and slid over the line with Slade adding the extras.
Davies was wide with a 30-metre drop goal attempt, leaving the Chiefs 17-10 ahead at half-time, but he soon made amends in the second half with a penalty.
Left-wing Mark Foster then dropped the ball with the line at his mercy but, thankfully for the Chiefs, the referee pulled play back for a penalty for offside in front of the posts and Slade restored a seven-point advantage for the home side.
Slade stretched the lead to 10 points with another penalty before the Chiefs had to play the final five minutes with 14 men when, having used all their replacements, Dave Ewers had to be helped from the pitch with a leg injury.
Three penalties during the final quarter from replacement Aled Thomas saw the
Scarlets claim their first win in this season's LV= Cup at the expense of
regional rivals Cardiff Blues.
Three penalties during the final quarter from replacement Aled Thomas saw the Scarlets claim their first win in this season's LV= Cup at the expense of regional rivals Cardiff Blues who were dged out 22-16.
The visitors, who had opened their Anglo-Welsh campaign with a win over Wasps last weekend, led 13-3 during the opening half thanks to a try from flanker Luke Hamilton and eight points from fly-half Gareth Davies.
But the Scarlets hit back through a converted penalty try and a Liam Williams penalty to level.
Davies put the Blues back in front, but Thomas stepped up to give the hosts the victory.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.