Welsh went down 23-16 at Northampton last weekend and currently lie 10th in the Aviva Premiership with 15 points from their opening nine fixtures.
The hosts were free to select winger Danny Caprice after his citing for an alleged dangerous tackle was dismissed in midweek.
George Skivington returns to the London Irish side for the Exiles' trip to the Kassam.
Skivington will partner Bryn Evans in the second row with Matt Garvey moving to the back row.
Jebb Sinclair is named as a replacement after returning from his loan with Western Province in South Africa.
London Welsh: 15 Tom Arscott, 14 Dan Caprice, 13 Sonny Parker, 12 Hudson Tonga'uiha, 11 Nick Scott, 10 Gordon Ross, 9 Tyson Keats, 8 Adam Balding, 7 Ed Jackson, 6 Daniel Browne, 5 Kirill Kulemin, 4 Jonathan Mills (capt), 3 Paulica Ion, 2 Neil Briggs, 1 Franck Montanella.Replacements: 16 Greg Bateman, 17 Tom Bristow, 18 James Tideswell, 19 Matt Corker, 20 Alfie To'oala, 21 Jamie Stephenson, 22 Alex Davies, 23 Seb Jewell.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Sailosi Tagicakibau, 12 Shane Geraghty, 11 Anthony Watson, 10 Ian Humphreys, 9 Darren Allinson, 8 Chris Hala'ufia, 7 Matt Garvey, 6 Declan Danaher (c), 5 Bryn Evans, 4 George Skivington, 3 Leo Halavatau, 2 Brian Blaney, 1 Max Lahiff.Replacements 16 Gerard Ellis 17 Jerry Yanuyanutawa, 18 Halani Aulika, 19 Kieran Low, 20 Jebb Sinclair, 21 Jamie Gibson, 22 Steven Shingler, 23 Jack Moates.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.