In the only alteration to the back-line, Quins director of rugby Conor O'Shea has named Ugo Monye who will return on the right wing in place of Tom Williams.
Will Collier will start at tighthead prop replacing James Johnston, with Charlie Matthews starting in the second row in place of Olly Kohn.
Chris Robshaw returns to captain the team and will be joined in the back row by Nick Easter and Tom Guest.
Related Articles:
Heineken Cup Round 4 Preview
Treviso v Leicester preview
Exeter v Scarlets preview
Ulster v Northampton preview
Calvisano v Bath preview
Gloucester v L Irish preview
Saracens v Munster preview
Toulon v Sale preview
Among the replacements, Jordan Turner-Hall returns with Sam Twomey and Kyle Sinckler looking to make their first Heineken Cup appearances of the season.
Meanwhile, for Zebre, boss Christian Gajan has made eight changes to his run-on side that lost 57-14 to Quins last weekend in Parma.
Australian utility back Daniel Halangahu is named at inside centre to partner Samuele Pace in a new-look midfield combination. They are preferred to Gonzalo Garcia and Matteo Pratichetti.
Alberto Chillon starts at scrum-half in place of Tito Tebaldi in the only other back-line change.
Filippo Ferrarini takes over from Mauro Bergamasco at openside flank with Mike Van Vuren coming in for Quintin Geldenhuys at lock.
As well as this, there is also a brand new front-row with Luca Redolfini, Davide Giazzon and Andrea de Marchi replacing David Ryan, Carlo Festuccia and Matias Aguero.
Harlequins: 15 Mike Brown, 14 Ugo Monye, 13 Matt Hopper, 12 Tom Casson, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Tom Guest, 5 George Robson, 4 Charlie Matthews, 3 Will Collier, 2 Joe Gray, 1 Mark Lambert. Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Kyle Sinckler, 19 Sam Twomey, 20 Luke Wallace, 21 Karl Dickson, 22 Ben Botica, 23 Jordan Turner-Hall.
Zebre: 15 Ruggero Trevisan, 14 Giovanbattista Venditti, 13 Samuele Pace, 12 Daniel Halangahu, 11 Leonardo Sarto, 10 Luciano Orquera, 9 Alberto Chillon, 8 Dries van Schalkwyk, 7 Filippo Ferrarini, 6 Nicola Cattina, 5 Josh Sole, 4 Mike Van Vuren, 3 Luca Redolfini, 2 Davide Giazzon, 1 Andrea de Marchi.
Replacements: 16 Andrea Manici, 17 Carlo Fazzari, 18 Salvatore Perugini, 19 Nicola Belardo, 20 Filippo Cristiano, 21 Luca Martinelli, 22 Matteo Pratichetti, 23 Gonzalo Garcia.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
