Premiership champions Harlequins have made two changes to the side that beat Leicester for Friday's clash with Sale at Salford City Stadium.
In the backs, Karl Dickson returns to start at scrum-half for Danny Care who is on England duty alongside Mike Brown, Joe Marler and Chris Robshaw.
Ben Botica continues at fly-half while Nick Evans recovers from an ankle injury which ruled him out of last week's fixture. Evans will be fit to return next week against the Exeter Chiefs.
In the forwards, Tom Guest has not fully recovered from a knock picked up during the win against Leicester, so Captain Nick Easter returns to the back-row alongside Maurie Fa'asavalu and Luke Wallace.
With Botica starting, Rory Clegg returns from Leeds and is is named among the replacements.
Meanwhile, Sale Sharks are hoping to maintain their winning run that started four games ago with a win over Scarlets in the LV-Cup.
Since then, the Sharks have been to Wasps and inflicted their first defeat at Adams Park this season and added the scalps of Exeter Chiefs and London Welsh.
Harlequins however are probably the toughest test yet, having won their last five away games. Their last defeat away from the Stoop was last November when they lost 18-21 to Bath at The Rec.
Sale Sharks: 15 Rob Miller, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Will Cliff, 8 James Gaskell 7 David Seymour (c), 6 Dan Braid, 5 Kearnan Myall, 4 Fraser McKenzie, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison. Replacements: 16 Marc Jones, 17 Eifion Lewis-Roberts, 18 Tony Buckley, 19 Tom Holmes, 20 Richie Vernon, 21 Cillian Willis, 22 Nick Macleod, 23 Will Addison.
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Ben Botica, 9 Karl Dickson, 8 Nick Easter (c), 7 Luke Wallace, 6 Maurie Fa'asavalu, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Sam Twomey, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 George Lowe.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.