England coach Stuart Lancaster is sure his changes will not have a detrimental effect in Sunday's Six Nations clash with Italy at Twickenham.
Lancaster has made five changes to his starting line-up following the victory over France two weeks ago.
Three changes in the pack see full debutant Mako Vunipola, Tom Youngs and James Haskell brought in, while Danny Care partners Toby Flood in a new pair of halves.
"They (Care and Ben Youngs) are unbelievably close. They are both high-quality players, in great form and in great condition and pushing each other," Lancaster said.
"Danny Care has waited patiently for his opportunity. In freshening the team up, sometimes when you have a guy who is desperate to play that can help the team."
Vunipola and Tom Youngs both made strong impressions off the bench against France, tightening up an English defence in the closing stages.
Lancaster added: "Mako gets his first start and everyone is delighted with that. He has thoroughly deserved his chance and we are looking forward to seeing how he goes."
Italy coach Jacques Brunel has altered his side even more, opting for seven changes including the return of skipper Sergio Parisse after his suspension was reduced.
Luciano Orquera returns at fly-half and will hope for a return to the form that saw him inspire the Azzurri to a memorable victory against France on the opening weekend.
Italy are predictably massive underdogs heading into the clash having never beaten England and anything other than a win for the Grand Slam hopefuls would be classed as one of the biggest upsets in the competition's history.
England: 15 A Goode, 15 C Ashton, 13 M Tuilagi, 12 B Barritt, 11 M Brown, 10 T Flood, 9 D Care, 8 T Wood, 7 C Robshaw, 6 J Haskell, 5 G Parling, 4 J Launchbury, 3 D Cole, 2 T Youngs, 1 M Vunipola.
Replacements: 16 D Hartley, 17 D Wilson, 18 J Marler, 19 C Lawes, 20 T Croft, 21 B Youngs, 22 F Burns, 23 B Twelvetrees.
Italy: 15 A Masi, 14 G Venditti, 13 G Canale, 12 G Garcia, 11 L McLean, 10 L Orquera, 9 E Gori, 8 S Parisse, 7 R Barbieri, 6 A Zanni, 5 J Furno, 4 Q Geldenhuys, 3 M Castrogiovanni, 2 L Ghiraldini, 1 A De Marchi.
Replacements: 16 D Giazzon, 17 A Lo Cicero, 18 L Cittadini, 19 A Pavanello, 20 F Minto, 21 S Favaro, 22 T Botes, 23 T Benvenuti.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.