Round Two of the Pro12 competition sees both the reigning champions and the European champions in action on Friday.
The current title holders, Munster, travel to Scotland to face Glasgow Warriors, with the prospect that another victory could see them set a new tournament record for successive wins.
Meanwhile the European champions, Leinster will be hoping to put their opening round defeat at Ospreys behind them when they welcome another Welsh region, Newport Gwent Dragons, to the RDS in Dublin.
The action switches to Italy for the first of three games on Saturday, Aironi hosting Ulster at the Stadio Zaffanella.
The visitors have an impressive record against the hosts, so it will be no easy task for the Italian outfit to try and secure their second ever victory in the tournament.
The fourth Irish province, Connacht, are also in action on Saturday, with Scarlets the visitors to the redeveloped Sportsground in Galway. Connacht repeated their 2010/11 opening day success this season, and will be looking to put together back to back victories at the start of a season for the first time since 2005/06.
The final game on Saturday is at the Liberty Stadium where Ospreys welcome Edinburgh. Ospreys lie second in the table after just failing to record a bonus point in their opening round success against Leinster, and will be hoping to repeat or even better that result against their Scottish opponents.
The round wraps up in Wales on Sunday with Benetton Treviso's trip to Cardiff. Blues are top of the table after their bonus point win in Edinburgh last weekend, and will be looking to consolidate that position by denying Treviso a first ever victory outside of Italy.
We look at all the Round Two action!
Friday, September 9:
Glasgow Warriors v Munster
(Firhill Stadium - 19.30)
Glasgow Warriors recorded a fourth straight tournament defeat in the Pro12 competition match at Ulster on Friday, but have not lost their opening two encounters since season 2007/08. The Warriors' only victory in their last five games at Firhill was 25-17 over Benetton Treviso on 18 March.
Another Munster victory will see them set a new tournament record with a 12th successive victory, surpassing Leinster's previous mark set in 2001-2002. The Munstermen have won their last six games against Scottish opponents.
Glasgow's only victory in their last six encounters with Munster was 22-9 at Firhill on 4 September 2009.
Glasgow Warriors: 15 Stuart Hogg, 14 Federico Aramburu, 13 Rob Dewey, 12 Troy Nathan, 11 Colin Shaw, 10 Duncan Weir, 9 Henry Pyrgos, 8 Ryan Wilson, 7 Chris Fusaro, 6 Rob Harley (captain), 5 Nick Campbell, 4 Tom Ryder, 3 Mike Cusack, 2 Pat MacArthur, 1 Ryan Grant.
Replacements: 16 Finlay Gillies, 17 Ed Kalman, 18 Gordon Reid, 19 James Eddie, 20 Rory Pitman, 21 Colin Gregor, 22 Scott Wight, 23 Peter Horne.
Munster: 15 Johne Murphy, 14 Doug Howlett, 13 Danny Barnes, 12 Lifeimi Mafi, 11 Simon Zebo, 10 Ian Keatley, 9 Peter Stringer, 8 James Coughlan, 7 Niall Ronan, 6 Peter O'Mahony (captain), 5 Mick O'Driscoll, 4 Billy Holland, 3 Wian Du Preez, 2 Damien Varley, 1 John Hayes.
Replacements: 16 Denis Fogarty, 17 Marcus Horan, 18 Stephen Archer, 19 Dave Foley, 20 Tommy O'Donnell, 21 Duncan Williams, 22 Scott Deasy, 23 Tom Gleason.
Referee: Dudley Phillips (Ireland)
Assistant Referees: Neil Paterson, Bob Nevins (both Scotland)
Leinster v Newport Gwent Dragons
(RDS Dublin - 19.35)
Leinster have suffered just one bigger defeat in the history of the tournament than their 3-27 reversal at Ospreys last weekend, whilst you have to go right the way back to season 2003/04 to discover the last time that Leinster lost both their opening fixtures of a new season.
Newport Gwent Dragons tripped up 12-20 at Munster in the Pro12 competition last Saturday, but have not lost their opening two fixtures in the competition since season 2008/09. The Dragons have won just once in Ireland since October 2004: 16-14 at Ulster on 19 September 2008.
Leinster won both encounters last season, whilst the Men from Gwent have lost all eight previous matches they have played on Leinster soil.
Leinster: 15 Isa Nacewa, 14 Fionn Carr, 13 Brendan Macken, 12 Eoin O'Malley, 11 David Kearney, 10 Ian Madigan, 9 Cillian Willis, 8 Rhys Ruddock (captain), 7 Dominic Ryan, 6 Kevin McLaughlin, 5 Devin Toner, 4 Damian Browne, 3 Jamie Hagan, 2 Richardt Strauss, 1 Heinke van der Merwe.
Replacements: 16 Aaron Dundon, 17 Jack McGrath, 18 Jack O'Connell/ Nathan White, 19 Mark Flanagan, 20 Leo Auva'a, 21 John Cooney, 22 Mat Berquist, 23 Darren Hudson.
Newport Gwent Dragons: 15 Martyn Thomas, 14 Adam Hughes, 13 Tom Riley, 12 Pat Leach, 11 Mike Poole, 10 Jason Tovey, 9 Joe Bedford, 8 Hugo Ellis 7 Gavin Thomas, 6 Andrew Coombs, 5 Rob Sidoli, 4 Adam Jones, 3 Ben Castle, 2 Tom Willis, 1 Phil Price.
Replacements: 16 Rhys Buckley, 17 Nathan Williams, 18 Dan Way, 19 Lewis Evans, 20 Jevon Groves, 21 Wayne Evans, 22 Steffan Jones, 23 Jamie Smith.
Referee: Andy Macpherson (Scotland)
Assistant Referees: Michael Black, Richard Kerr (both Ireland)
TMO: Tony Redmond (Ireland)
Saturday, September 10
Aironi v Ulster
(Stadio Zaffanella - 15.00)
Aironi Rugby are still looking to add to their solo victory in this tournament, which was gained against Connacht at Stadio Zaffanella in March. Aironi lost 9-32 at Scarlets in round one of the Pro12 competition last Sunday.
Ulster have won nine of their last ten regular season encounters in the competition, and have won all ten previous matches against Italian opposition in all tournaments.
The two sides met on four occasions last season with the Ulstermen conceding just one try whilst scoring 14 themselves.
Ulster: 15 Adam D'Arcy, 14 Criag Gilroy, 13 Darren Cave, 12 Nevin Spence, 11 Ian Whitten, 10 Ian Humphreys, 9 Paul Marshall, 8 Chris Henry (captain), 7 Willie Faloon, 6 Pedrie Wannenburg, 5 Dan Tuohy, 4 Tim Barker, 3 Jerry Cronin, 2 Andy Kyriacou, Paddy McAllister.
Replacements: 16 Nigel Brady, 17 Declan Fitzpatrick, 18 Adam Macklin, 19 Lewis Stevenson, 20 Robbie Diack, 21 Ian Porter, 22 Paddy Jackson, 23 Luke Marshall
Referee: Neil Hennessy (Wales)
Assistant Referees: Alan Falzone, Giuseppe Vivarini (both Italy)
Connacht v Scarlets
(Sportsground - 15.15)
Connacht beat Benetton Treviso 11-9 in Italy last weekend in the opening round of the Pro12 competition, but have not won their opening two fixtures in the competition since 2005/06. Connacht's 12-26 defeat at the Sportsground in their last home game ended a six game home winning run.
Scarlets also beat Italian opposition in round one, overcoming Aironi 32-9 at Parc y Scarlets. The Welshmen have won their last three matches in the tournament but are winless in their last seven encounters against opponents from Ireland.
The last four matches between the two sides have all been won by the home side on the day, whilst the Scarlets have not been victorious at the Sportsground since January 2009.
Referee: Marius Mitrea (Italy)
Assistant Referees: Leo Colgan, Peter Roche (both Ireland)
TMO: Dermot Moloney (Ireland)
Ospreys v Edinburgh
(Liberty Stadium - 18.30)
Ospreys beat Leinster 27-3 at Liberty Stadium in round one of the Pro12 competition, and have lost just one game at the venue in their last 13 matches in all competitions. Ospreys have not lost at home to a Scottish team since Edinburgh were the visitors on 25 April 2009.
Edinburgh Rugby tripped up at home to Cardiff Blues last Friday and have now lost back to back matches in the tournament. Edinburgh's only away victory since December 2009 was 10-9 in Aironi on 2 October 2010. The Scotsmen have lost on their last six visits to Wales in all competitions.
The last four clashes between the two sides have all been won by the home side on the day, whilst Edinburgh have a won 2, lost 4 record in previous visits to Liberty Stadium.
Referee: David Wilkinson (Ireland)
Assistant Referees: James Jones, Ian Davies (both Wales)
TMO: Tony Rowlands (Wales)
Sunday, September 11
Cardiff Blues v Benetton Treviso
(Cardiff City Stadium - 15.45)
Cardiff Blues top the Pro12 competition table courtesy of their bonus point victory in Edinburgh last Friday. The Blues have not won their opening two games of a season since 2007/08. The Welshmen have won all nine previous matches they have played against Italian opposition in all competitions.
Benetton Treviso pushed Connacht all the way on Saturday and became the only side in round one to record a losing bonus point in their 9-11 defeat to the Irishmen. Treviso are still looking for that elusive first victory outside of Italy since December 2007.
The Blues won both previous encounters with Benetton Treviso. Whilst Treviso have lost on both previous visits to the City of Cardiff: 16-23 to Cardiff RFC at the Arms Park in December 1999 and 9-20 to the Blues at Cardiff City Stadium in April.
Cardiff Blues: TBC
Benetton Treviso: TBC
Referee: Andrew McMenemy (Scotland)
Assistant Referees: Leighton Hodges, Sean Brickell (both Wales)
TMO: Neil Ballard (Wales)
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