One of the biggest weekends in the European club rugby calendar will kick-off with the first Amlin Challenge Cup quarterfinal contest, between last season's finalists, Stade Francais and the Exeter Chiefs.

The theme of cross-channel rivalry continues with the heavyweight clash of the 2010 finalists, Toulon, and reigning champions, Harlequins, who qualified from this season's Heineken Cup, at Stade Félix Mayol.

Then it will be the turn of London Wasps - tournament winners in 2003 - to go head-to-head with another Heineken Cup qualifier, Biarritz Olympique, at Adams Park, before a weekend of high-quality action is rounded off with the meeting of Brive and the Scarlets from Wales.

The five Amlin Challenge Cup Pool winners secured automatic places in the quarterfinals and they were joined in the last eight by Biarritz, Harlequins and the Scarlets – the third, fourth and fifth best-placed runners-up from the Heineken Cup Pools.

Following the completion of the semifinal draw last Sunday, the much anticipated clashes of Toulon and Harlequins, and of London Wasps and Biarritz, will have the added incentive of offering the winners a home semifinal and taking them one step closer to the London 2012 Amlin Challenge Cup final at the Twickenham

Quarterfinal fixtures:

Thursday, April 5: Stade Francais v Exeter Chiefs
Friday, April 6: Toulon v Harlequins
Saturday, April 7: London Wasps v Biarritz
Sunday, April 8: Brive v Scarlets