Lock James Percival, full back Errie Claassens and scrum half Shaun Perry are all handed their full league debuts by the Warriors.
Marcel Garvey and Miles Benjamin will start on the wings, while fly-half Andy Goode also features and Kai Horstmann will skipper the side from the back row.
Sale will also have seven new faces on show at Sixways, three of whom have never played before in the Premiership.
Former Bath and Exeter player Andrew Higgins is involved after completing his move on Friday, while Joe Ward, Kearnan Myall and Mark Easter also play.
Joaquin Tuculet, Vadim Cobilas and Fraser McKenzie will get their first taste of England's top division as the Sharks look to improve on their disappointing 10th place finish last season.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
