Sam Smith will play on the wing in place of Ross Chisholm, who will be sidelined for a number of weeks with an ankle injury.
Joe Marler is unavailable after being given a three-week ban for striking, meaning Mark Lambert is brought into the line-up at prop. The rest of the pack remains unchanged from last Friday's win over Northampton.
Quins will be looking to continue a run of form that has seen them win five of their last six matches in all competitions, with their only defeat in that period being a 13-16 defeat to Saracens in May.
Gloucester hand a first start to Australian hooker Nathan Charles as coach Bryan Redpath makes several changes to the line-up that comfortably defeated Worcester.
Charles will replace hooker Darren Dawidiuk in the front row and plays alongside Nick Wood and Rupert Harden, who comes into the team for Dario Chistolini at tighthead.
With Will James banned for one match, Tom Savage keeps his place at lock, with Alex Brown joining him in the second row having missed out at home to the Warriors last weekend. Darren Dawidiuk is also dropped.
Brett Deacon will make his first start of the season at No. 8 and Matt Cox moves to openside flanker as Andy Hazell is absent due to a thumb injury.
There are also changes in the backs, with Henry Trinder starting at outside centre in place of Jonny May, who is dropped to the bench, while Freddie Burns is preferred to Tim Taylor at fly-half.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.