Quins are currently at the top of the Premiership standings after winning all four of their opening matches.
The solitary change sees Seb Stegmann start on the left wing in place of Ugo Monye, who picked up a knock against Worcester last time out but is expected to be fit for next week's clash with Leicester.
The starting pack remains unchanged from the narrow win over Worcester, with Olly Kohn set to make his 100th competitive appearance for Quins.
There are changes among the replacements, however, as Joe Marler returns from suspension while James Johnston, Will Skinner and Tom Casson all come back from injury.
Sale also make just one change for the clash, with new captain Sam Tuitupou, who made his debut from the bench last week, starting at inside centre.
Will Addison switches to the outside of the midfield paring, while Andre Higgins drops to the bench to make way.
The Sharks are on a run of three straight victories but executive director Steve Diamond is keeping his feet on the ground ahead of the clash with the table-toppers.
"Nobody is getting carried away with the start we have made," he said.
"There are no dramas here. We understood from the minute that we all arrived at the club in the summer what we were going to try and do and we are nowhere near the finished article.
"The players and I know that in every game we need to improve. We are very fit, and our spirit and some very good play have guided us to this position.
"All the lads are enjoying themselves but we are looking no further ahead than Saturday when we know we will be up against a very good side."
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