Wasps boss Dai Young has rung the changes for the game, making eight alterations to the team that suffered a shock loss to Dragons in the LV= Cup last time out.
Thompson takes over the number two jersey and scrum-half Joe Simpson is handed his first start. Riki Flutey, who has spent the past four weeks out injured, returns to the fray while Nick Robinson, Ben Broster, Tim Payne, Jonathan Poff and Richard Birkett are all handed starting berths.
Thompson made his Premiership bow 13 years ago but despite having plenty of game time under his belt he admits that a new challenge is still a great thrill.
"I can't wait to get out there and am delighted to get my first start because there is a lot of competition here for the number two shirt. I've thoroughly enjoyed my first few weeks with the club and I feel fresh and ready for action," said the hooker.
Worcester are currently struggling with just nine points from their first six games of the season but despite this, Young is not taking anything for granted.
"We know that Worcester are very strong at home and away wins are always difficult, but if we want to do well in this league we have got to start picking up results on the road," he asserted.
Worcester have been handed a massive boost ahead of the clash with the return to action of scrum-half Shaun Perry.
The number nine suffered what was feared to be a season-ending knee injury in late September but has made a remarkable recovery.
Perry's return is the only change to the starting line-up that faced London Irish in the Warriors' last league fixture.
There are, however, a number of changes on the bench with Tongan hooker Aleki Lutui returning from international duty while prop George Porter replaces the injured Ceri Jones. Flank Sam Betty is rewarded for his good Cup form with a place on the bench, as is utility-back Chris Pennell.
Worcester: 15 Errie Claassens, 14 Marcel Garvey, 13 Alex Grove, 12 Dale Rasmussen (c), 11 Miles Benjamin, 10 Andy Goode, 9 Shaun Perry, 8 Chris Jones, 7 Jake Abbott, 6 Neil Best, 5 Craig Gillies, 4 James Percival, 3 Tevita Taumoepeau, 2 Ed Shervington, 1 Matt Mullan.Replacements: 16 George Porter, 17 Aleki Lutui, 18 Oliver Tomaszczyk, 19 Adam Balding, 20 Sam Betty, 21 Ollie Frost, 22 Joe Carlisle, 23 Chris Pennell.
Wasps: 15 Hugo Southwell, 14 Tom Varndell, 13 Chris Bell, 12 Riki Flutey, 11 Christian Wade, 10 Nick Robinson, 9 Joe Simpson, 8 John Hart (c), 7 Jonathan Poff, 6 Richard Birkett, 5 Marco Wentzel, 4 Ross Filipo, 3 Ben Broster, 2 Steve Thompson, 1 Tim Payne.Replacements: 16 Rob Webber, 17 Zak Taulafo, 18 Jeremy Castex, 19 Joe Burton, 20 Matt Everard, 21 Nic Berry, 22 Ryan Davis, 23 Chris Mayor.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.