Steve Shingler is named at fly-half in place of Adrian Jarvis, and Topsy Ojo's return on the right wing means Tom Homer moves to the other flank.
Shontayne Hape returns to the midfield in place of Jonathan Spratt and he partners Joe Ansbro and the one change to the pack sees Richard Thorpe reinstalled at No 8.
Exeter coach Rob Baxter makes four changes to his starting line-up as the Chiefs aim for a first ever win over London Irish.
The Exiles are one of only two teams Exeter are yet to beat since their arrival to the top flight - Bath are the other - and they are in excellent form having won five on the spin in all competitions, their most recent victory being over the Dragons in the Amlin Challenge Cup.
Hoani Tui comes in at loosehead for Brett Sturgess, whilst James Scaysbrook - who sat out both Amlin games against the Welsh region - returns at flanker in place of Ben White.
In the backs Haydn Thomas is recalled to the No 9 shirt at Pat Phibbs' expense, whilst Argentinian flyer Gonzalo Camacho comes in for Josh Tatupu on the wing.
London Irish: Armitage, Ojo, Ansbro, Hape, Homer, Shingler, Allinson, Dermody, Paice, Ion, Evans, Garvey, Danaher, Gibson, Thorpe
Replacements: Buckland, Corbisiero, Halavatau, Casey, Gray, Thompstone, Jarvis, Hodgson
Exeter: Arscott, Camacho, Sestaret, Dollman, Jess, Mieres, Thomas, Tui, Alcott, Mitchell, Hayes, Bentley, Baxter, Scaysbrook, Phillips
Replacements: Clark, Sturgess, Andress, Muldowney, Johnson, Barrett, Steenson, Shoemark
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
