The 20-year-old, who had been tipped in some quarters for a place in Stuart Lancaster's England Six Nations squad, has been one of the stars of the Aviva Premiership season, and is currently the league's top try scorer with seven.
But the groin injury he picked up in the recent defeat to Worcester requires an operation and he faces a lengthy spell on the sidelines.
His absence robs Dai Young's side of one of their most potent attacking threats at a time when they are enduring their worst run of league form in a decade, a run of six straight defeats dropping them to 11th in the table.
A club statement read: "London Wasps winger Christian Wade has been ruled out for three months following a groin injury picked up in a recent game against Worcester. He will have surgery tonight."
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