The league's bottom club show three changes from the side that suffered a fifth straight defeat of the season at Bath last weekend.
Wing Will Addison replaces Tom Brady, who is serving a two-week suspension, while Scotland international forwards Richie Gray and Richie Vernon both start. Fly-half Danny Cipriani is again on replacement bench duty.
Leicester welcome back scrum-half Ben Youngs, who makes his first appearance since suffering a shoulder injury on England's summer tour to South Africa.
George Ford partners Youngs at half-back instead of Toby Flood, who is on the bench, while centre Manu Tuilagi returns from injury and former London Irish flanker Richard Thorpe makes his Tigers debut.
Sale: 15 R Miller, 14 W Addison, 13 J Leota, 12 S Tuitupou, 11 M Cueto, 10 N Macleod, 9 C Willis, 1 E Lewis-Roberts, 2 T Taylor, 3 T Buckley, 4 R Gray, 5 F McKenzie, 6 R Vernon, 7 D Seymour (capt.), 8 A Powell. Replacements: 16 J Ward, 17 R Harrison, 18 V Cobilas, 19 K Myall, 20 J Gaskell, 21 N Fowles, 22 D Cipriani, 23 M Jennings.
Leicester: 15 N Morris, 14 A Thompstone, 13 M Tuilagi, 12 A Allen, 11 V Goneva, 10 G Ford, 9 B Youngs, 1 L Mulipola, 2 T Youngs, 3 M Castrogiovanni, 4 E Slater 5 G Kitchener, 6 J Crane (c), 7 R Thorpe, 8 T Waldrom.
Replacements: 16 G Chuter 17 B Stankovich, 18 D Cole, 19 R Andrew, 20 B Deacon, 21 S Harrison, 22 T Flood, 23 M Smith.
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