Among the replacements, Rob Buchanan comes in to provide cover at hooker, while George Lowe returns from injury and will look to make his first appearance since the November 16.
Meanwhile, Irish have announced an unchanged starting XV for the local derby.
Director of Rugby Brian Smith retains the starting line-up that played Leicester Tigers at Madejski Stadium last Saturday. There are three changes among the replacements where George Skivington returns from injury to cover the second row. Steven Shingler and Friday's signing Patrick Phibbs provide half-back cover.
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