Montpellier have struggled to make an impact in the Top 14 this season but on Saturday they will look to catch European Cup holders Leinster cold and make it a memorable debut in the competition.
To achieve that, though, they will need to recapture last season's astonishing form that saw them go all the way to the Top 14 final where they lost to four-time European champions Toulouse.
Whilst Leinster are battle-hardened European campaigners and showed great resilience to come back from 22-6 down at half-time to beat Northampton 33-22 in last season's final, Montpellier could pull off a shock.
They will have their World Cup absentees back and will hope flyhalf Francois Trinh-Duc will be in as scintillating form as he was in the 8-7 defeat by the All Blacks in the Final, where his introduction sparked the French into their best rugby of the tournament.
Should he manage to do so it will get the majority of the 32,000 spectators in the stadium belonging to the football side behind them and could rattle a Leinster side who will be without inspirational duo, Brian O'Driscoll and Shane Horgan.
Indeed this will be a good test for the Irish province as O'Driscoll - who will travel and perform waterboy duties during the match - and Horgan are slated to be out for six and four months respectively so they will be shorn of their talents for most of the pool stage.
Leinster coach Joe Schmidt admits that his champions face a demanding challenge against a side that will be packed with talent.
"They've made a big thing of the first game against us and are looking to sell out Stade de le Mosson," he said.
"I think that's a big thing for them.
"They've haven't started the French league well [they've won just two of their nine matches] but they've been deprived of a number of quality players and that's been frustrating for them.
"But at the same time, Marmuka Gorgodze's, Sakiusa Matadigo's, Francois Trinh-Duc and Fulgence Ouedraogo should all be back for them and they have got some good imports.
"I know Fabien Galthie [Montpellier head coach] pretty well and spent a bit of time with him at Stade Francais about six years ago. I know a little bit about how he thinks and he'd know every bit as much about me."
Galthie's fellow head coach Eric Bechu said that he hoped the side would do themselves justice.
"Now we have achieved our goal of being in the European Cup, we are going to try and do something memorable," said Bechu.
"But If I was to say we would try and qualify for the knockout stages with Leinster in the pool, you would think I was mad and you would be correct," he added disarmingly.
Unlike Montpellier, Biarritz are experienced European Cup campaigners - they have lost in two finals - but they equally need a boost this weekend after a disastrous opening to their Top 14 campaign which sees them lie bottom with just one win in nine games.
A trip to Welsh side Ospreys would not usually be thought of as the best way to remedy a poor run, but Biarritz stalwart Imanol Harinordoquy said this could be the best way to turn their season round.
"We have nothing to lose against a side that on paper is stronger than us," said the 31-year-old No.8, who was outstanding in the World Cup final.
"The championship has been a little bit complicated for us but hopefully this will give us some much-needed oxygen."
Ospreys also go into the clash with all their players from the World Cup back in contention with some of them having played in the 9-9 draw with the Scarlets last weekend.
Ospreys coach Sean Holley saw much to be encouraged by that performance.
"We have to go into the Biarritz game knowing we haven't won - we haven't lost, which is important - but there was intensity around the tackle area, the Scarlets approach to it, it was good preparation for us."
Round One fixtures:
Friday, November 11:
Harlequins v Connacht, The Stoop - 20.00; 20.00 GMT
Racing Métro v Cardiff Blues, Stade Yves du Manoir - 21.00; 20.00 GMT
Saturday, November 12:
London Irish v Edinburgh, Madejski Stadium - 13.30; 13.30 GMT
Aironi v Leicester Tigers, Stadio Brianteo - 14.30; 13.30 GMT
Montpellier v Leinster, Stade de la Mosson - 13.30; 13.30 GMT
Scarlets v Castres Olympique, Parc y Scarlets - 15.00; 15.00 GMT
Ospreys v Biarritz Olympique, Liberty Stadium - 15.40; 15.40 GMT
Ulster v Clermont Auvergne, Ravenhill - 15.40; 15.40 GMT
Munster v Northampton Saints, Thomond Park - 18.00; 18.00 GMT
Sunday, November 13:
Glasgow Warriors v Bath, Firhill Arena - 12.45; 12.45 GMT
Saracens v Benetton Treviso, Vicarage Road - 15.00; 15.00 GMT
Toulouse v Gloucester, Stade Ernest Wallon - 16.00; 15.00 GMT
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.