Second-half tries from Conor Murray, Peter O'Mahony, Sean Dougall and Damien Varley sealed the bonus-point victory for the hosts while Ian Keatley kicked three penalties and two conversions after their opening-round defeat to Racing Metro.
For Edinburgh the defeat all but ends their hopes of repeating last season's progress to the latter stages of the competition following their heavy loss to Saracens last weekend.
Munster dominated the opening 40 minutes but led just 6-0 at the break following two penalties from Keatley, who started in place of the injured Ronan O'Gara.
Munster's dominance of possession and territory finally paid off 10 minutes into the second half when Murray darted through a gap around the fringes and slide under the posts following a series a series of busting surges from the hosts.
Keatley added the simple conversion and a third penalty in the 56th minute to give the hosts a sizeable lead.
With 10 minutes remaining O'Mahony powered over from close-range following a driving lineout and Dougall grabbed Munster's third try of the afternoon after supporting a break away from Keatley.
The home fans roared Munster on in the final minutes as they hunted the bonus-point try and their pack delivered again as Varley crossed following another powerful driving maul.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.