Sale will hand Josh Beaumont his first start in Friday's Heineken Cup clash with Montpellier at the Salford City Stadium.
The 20-year-old, the son of the former England captain Bill Beaumont, makes the step up having joined the Sharks in the summer on a dual-contract with Fylde.
Although he has predominately played at lock, the same position as his father, Beaumont has been handed the number eight shirt to face the Top 14 outfit.
Captain Dave Seymour returns to join him in the back row, while Mark Cueto will partner Mark Jennings in the midfield.
Fit-again Tommy Taylor will return to action off of the bench.
Although Sale's hopes of qualifying for the knockout stages are now over, Montpellier remain in the hunt of overhauling leaders Toulon.
As result, they have named a strong looking line-up for the trip to Salford - with Francois Trinh-Duc, Johnnie Beattie, Mamuka Gorgodze and Santiago Fernandez among those starting.
Sale Sharks: 15 Cameron Shepherd, 14 Tom Brady, 13 Mark Cueto, 12 Mark Jennings, 11 Charlie Amesbury, 10 Danny Cipriani, 9 Will Cliff, 8 Josh Beaumont, 7 David Seymour, 6 James Doyle, 5 Tom Holmes, 4 Richie Gray, 3 Vadim Cobilas, 2 Marc Jones, 1 Aston Croall.
Replacements:16 Tom Cruse, 17 Ross Harrison, 18 Tony Buckley, 19 Kearnan Myall, 20 Tommy Taylor, 21 Nathan Fowles, 22 Rob Miller, 23 Jordan Davies.
Montpellier: 15 Pierre Bérard, 14 Timoci Nagusa, 13 Thomas Combezou, 12 Santiago Fernandez, 11 Yohann Artru, 10 Francois Trinh-Duc, 9 Benoit Paillaugue, 8 Johnnie Beattie, 7 Mamuka Gorgodze, 6 Fulgence Ouedraogo, 5 Aliki Fakate, 4 Mickael Demarco, 3 Maximiliano Bustos, 2 Agustin Creevy, 1 Mikheil Nariashvili.
Replacements: 16 Rassie van Vuuren, 17 Yvan Watremez, 18 Barry Fa'amausili, 19 Remy Martin, 20 Alexandre Bias, 21 Eric Escande, 22 Paul Bosch, 23 Lucas Amorosino.
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