Glasgow put an end to Northampton's hopes of a Heineken Cup quarter-final berth as Peter Horne's last-gasp try secured a 27-20 home win.
At a frosty Scotstoun Stadium on Saturday, Soane Tonga'uiha made his 200th appearance for the visitors.
But Gregor Townsend's players achieved the Warriors' first win in this season's tournament against their head coach's former club.
The match will be remembered for the wonderful final-minute try from Horne who ran half the length of the pitch before touching down.
For Glasgow the match provided only pride to be gained. Already unable to progress in the Heineken Cup after collating a miserable two points from their first five matches, Townsend made 10 changes to his squad following their match at Ravenhill against Ulster last week, including the return of Stuart Hogg at full-back.
The squad rotation suggests the priorities of the Warriors in the coming months, with the Glasgow side second in the RaboDirect PRO12.
For Northampton, who needed a bonus-point victory to keep their hopes of qualification alive, the same 15 players who narrowly defeated Castres at Franklin's Gardens last week started the match.
Despite the lunchtime kick-off the floodlights were, unlike the temporary stands behind either set of posts, at full capacity.
Northampton were looking for a good start, but Courtney Lawes gave away a penalty after 30 seconds which Ruaridh Jackson duly booted between the posts to give Glasgow an early three-point advantage.
Despite pressure from the visitors, the home side's was doubled thanks to Jackson's right boot 10 minutes later. Stephen Myler pulled it back to 6-3 with a simple penalty for Saints moments later, before Northampton almost secured the first of the four tries they would have needed for a bonus-point victory.
Jamie Elliott dashed to the left corner, only to be blocked off within touching distance of the line.
Despite Northampton's dominance in the early stages, it brought them little reward. Niko Matawalu's tenacity at scrum-half epitomised Glasgow's spirit.
Northampton eventually broke through after 30 minutes when a charging run from Dom Waldouck opened up the Glasgow defence and he scored under the posts, with Myler converting with ease.
With Jackson injured for Glasgow, replacement fly-half Scott Wight's first involvement was a difficult penalty attempt from 40 yards which failed to find the target.
By that stage the home crowd was growing increasingly frustrated by Welsh referee Leighton Hodges' reluctance to play advantage, and the 10-6 lead at half-time for Northampton hardly helped to temper the frustration.
Glasgow started the second half rejuvenated, taking the lead after 46 minutes through a try from Josh Strauss.
The South African flanker's raw power saw him overcome three opponents to reach the Northampton try-line, much as he did in the reverse fixture between the two teams at Franklin's Gardens in October, and give Glasgow a 13-10 lead.
The lead was to last until the hour mark as the quick feet of Samoan George Pisi, Northampton's top try-scorer this season, side-stepped tackles to find his way to the right corner of Glasgow's try-line.
The unconverted try was Pisi's sixth of the season, and his third against the Warriors.
Glasgow's Matawalu stole the lead yet again from Northampton however. The Fijian pinched possession and then ran the 30 yards required to score under the posts, leaving Wight with an easy conversion with 13 minutes left to play.
A late try from Northampton winger Ben Foden brought the scores level at 20-20, despite pleas of obstruction from the crowd.
It would be Glasgow that had the final say though thanks to an outstanding solo effort from Horne.
Overcoming several tackles from Saints players, Horne powered through to score arguably the best try of his career before booting the conversion himself.
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