England's interim head coach Stuart Lancaster has taken the strong disciplinary action because it was Care's second alcohol-related incident in three weeks.
The Harlequins scrum-half was fined for being drunk and disorderly after being arrested in the early hours of December 10, following his club's Heineken Cup defeat to Toulouse.
Although Care was also fined a "substantial" amount by Harlequins, England took no further disciplinary action on that occasion.
But after the latest incident over the festive season Lancaster has now decided to come down strongly on the 25-year-old, who missed the World Cup with a foot injury but was certain of a place in England's Six Nations plans.
The squad will be announced on January 11.
But Lancaster has met with Care, told him his behaviour is not what is expected of an England player and that he will not be included in either the senior or Saxons squads.
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