The hooker was ruled out of his side's first defeat of the season against London Irish last time out with an eye injury but returns for the European contest at Franklin's Gardens.
The other change in the forwards sees Rhys Oakley come in at No. 8, with some positional shuffling meaning it is lock Samu Manoa who drops out of the squad.
In the backs, George Pisi slots into the centres after recovering from a shoulder injury, while James Wilson also returns from injury to start at full-back with Vasily Artemyev switching to the wing. Luther Burrell and Noah Cato drop out.
South African forward Gerrit-Jan van Velze is named among the replacements after being eligible for selection again following his four-week ban.
Glasgow head coach Gregor Townsend has made three changes from the RaboDirect PRO12 away win over Cardiff Blues last Saturday.
Stuart Hogg makes his full return from an ankle injury as he lines up at full-back, while Ryan Grant comes in at loosehead prop and Tim Swinson starts in the second row.
Glasgow have gone for a six-two forward-back split on the bench as they anticipate a physical encounter with the Saints.
Northampton: 15 James Wilson, 14 Ken Pisi, 13 George Pisi, 12 Dom Waldouck, 11 Vasily Artemyev, 10 Stephen Myler, 9 Lee Dickson, 8 Rhys Oakley, 7 Tom Wood, 6 Phil Dowson, 5 Courtney Lawes, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Soane Tonga'uiha.
Replacements: 16 Mike Haywood, 17 Alex Waller, 18 Paul Doran Jones, 19 Mark Sorenson, 20 GJ Van Velze, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
Glasgow: 15 Stuart Hogg, 14 Tommy Seymour, 13 Alex Dunbar, 12 Peter Horne, 11 Sean Lamont, 10 Ruaridh Jackson, 9 Henry Pyrgos, 8 Ryan Wilson, 7 John Barclay, 6 Josh Strauss, 5 Al Kellock (c), 4 Tim Swinson, 3 Mike Cusack, 2 Dougie Hall, 1 Ryan Grant.
Replacements: 16 Finlay Gillies, 17 Ofa Fainga'anuku, 18 Gordon Reid, 19 Tom Ryder, 20 Chris Fusaro, 21 James Eddie, 22 Niko Matawalu, 23 Peter Murchie.
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