Borthwick was rested for the victory over Northampton but is named in the starting XV in one of four changes ahead of the Aviva Premiership tie.
Schalk Brits returns at hooker and Richard Wigglesworth gets the nod at scrum half with Neil de Kock benched, while Owen Farrell slots in at stand-off ahead of Charlie Hodgson.
The only other change sees James Short named on the wing in place of the rested Chris Ashton.
Meanwhile, Wales scrum-half Dwayne Peel returns to the Sale starting line-up after recovering from injury, replacing Cillian Willis.
Andy Powell is welcomed back at number eight, with Richie Vernon moving to openside flanker to replace captain Dave Seymour.
New signing Daniel Braid is named amongst the replacements.
Saracens: 15 Chris Wyles, 14 James Short, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 George Kruis, 4 Steve Borthwick (c), 3 Matt Stevens, 2 Schalk Brits, 1 Mako Vunipola.
Replacements: 16 Jamie George, 17 Rhys Gill, 18 Petrus du Plessis, 19 Mouritz Botha, 20 Nick Fenton-Wells, 21 Neil de Kock, 22 Charlie Hodgson, 23 Duncan Taylor.
Sale: 15 Rob Miller, 14 Tom Brady, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 Andy Powell, 7 Richie Vernon, 6 James Gaskell, 5 Kearnan Myall, 4 Richie Gray, 3 Tony Buckley, 2 Marc Jones, 1 Ross Harrison.
Replacements: 16 Aston Croall, 17 Alasdair Dickinson, 18 Eifion Lewis-Roberts, 19 Tom Holmes, 20 Daniel Braid, 21 Will Cliff, 22 Charlie Amesbury, 23 Cameron Shepherd.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.