The former Huddersfield and Wakefield winger, whose older brother Darrell was in the Leeds Rhinos team that lost to Warrington in the Challenge Cup final last Saturday, will be among a host of players making their farewell home appearances for the Tigers against Catalan Dragons on Sunday.
Castleford say they have had an approach for Griffin, who has made 21 appearances in his first season with the club, and are likely to release him early from his contract to enable coach Ian Millward to further review squad options for next season.
The Tigers, who finish the season at Hull on Saturday week, have already confirmed that Joe Arundel, who is joining Hull, Danny Orr, Ryan Hudson and Nick Youngquest, who are all retiring, and Stuart Jones will be making their last appearances at the Probiz Coliseum.
The match could also mark the penultimate appearances of prop Paul Jackson and stand-off Rangi Chase, who remains a target for Hull.
Chase and hooker Daryl Clarke are set to return from injury to face the Catalans and half-back Jamie Ellis will be back from suspension as Millward's men look to end a run of five consecutive defeats and avoid the wooden spoon.
Chase, the reigning Man of Steel, has not played since picking up a knee injury in the home defeat by Warrington in July while Clarke has spent three months on the sidelines with a knee injury.
Millward said: "Rangi Chase has been training very strongly so he will definitely return to the starting line-up on Sunday.
"Daryl has also worked extremely hard to get back to fitness ahead of time which is testament to his attitude, work ethic and our physio Ben Sterling.
"There is no doubt the return of our three best playmakers will give us a much-needed boost for the Catalans game.
"Rangi and Jamie have only played together once this season so it will be great to see that combination back on the field.
"It will be a particularly emotional day on Sunday with seven players not contracted to the club for 2013 and some playing the last home game of their careers. We hope to give them all the send off they deserve."
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